Dr. Shuyin Li
Chicago,IL
Summary
Experienced research professional with a strong academic background from the University of Chicago, specializing in immune-oncology. Proficient in molecular biology, cell biology, genetics, and immunology, with expertise in leading projects from conception through publication. Recognized for innovative research, awarded the Young Investigator Award in 2019, and known for exceptional mentorship and collaboration abilities. Detail-oriented team player with robust organizational skills, capable of managing multiple projects simultaneously with precision.
Overview
11
11
years of professional experience
Work History
Research Professional
University of Chicago
08.2019 - Current
Conducting research in immune-oncology under the supervision of Dr. Thomas Gajewski:
- Lead projects: research design, execution, analysis, and dissemination, Drafted manuscripts and publish results in peer-review journal ( Cancer Immunology Research )
- Mentor junior researchers: problem-solving, basic research training, Critical thinking
- Generating innovative ideas, collaborating with collaborating with fellow researchers, analyzing complex data
- Presentation projects in meetings (AACR and SITC)
Postdoctoral Researcher
University of Chicago
08.2016 - 07.2019
Studying Immune-Oncology in Dr. Thomas Gajewski's lab
- Conducted independent research and development to attain short and long-term objectives.
- Drafted manuscripts and presented findings at major conferences.
- Pursued independent and complementary research interests.
- Published research results in peer-reviewed ( Nature Communications ) journals and presented at seminars and SITC meetings ( Got Young Investigator Award 2019 ).
- Conducted a comprehensive review of related studies and authored a paper for Immunological Reviews.
Postdoctoral Researcher
University of Chicago
08.2014 - 07.2016
Research focused on study autoimmune disease
- Collaborated with a diverse team of experts to achieve research goals, resulting in the collaborative publication of a peer-reviewed paper in Cell Reports .
Intern
Fudan University
12.2013 - 04.2014
- Sorted and organized files, spreadsheets, and reports.
- Maintained accurate records and documentation of projects to inform stakeholders of progress and updates.
- Conducted extensive research for startup lab projects.
- Assisted in training students
Education
Ph.D. - Biology
China Agriculture University
Beijing, China12.2013
Ph.D. - Immunology
RIKEN
Yokohama, Japan09.2012
Bachelor of Science - Biology
China Agriculture University
Beijing, China06.2007
Skills
- Genome-wide CRISPR screen and NGS analysis
- Generating knockouts, knockdowns (stable or inducible), overexpression vectors
- Proficient in basic molecular biology techniques: qPCR, PCR, Western blot, DNA/RNA isolation, scRNA-sequence
- Creating knockout or knockdown cell lines (stable or inducible)
- Culturing human or mouse primary cells and cell lines
- Handling mouse ES cells
- Lentivirus transduction
- Car-T cell culture
- Primary T cell culture and stimulation
- Recombinant protein expression in cell line
- Generating reporter cell lines
- Flow cytometry analysis
- ELLISPOT assay
- ELISA (enzyme-linked immunosorbent assay)
- Cell sorting techniques
- Designing, developing, and validating therapeutic candidates in tumor models
- Generating tumor immunology mouse models
- Designing and creating knock-in and knock-out mouse models
- Conducting tumor preclinical experiments using GEM (genetically engineered mouse) tumor models and transplantation models
- Different dose of drug administration in tumor models (IP, IV, Intratumoral)
- Designing lipid synthesis experiments and performing mass spectrometry analysis
- Immunofluorescence (IF) staining of human tissues and cell lines
- Confocal imaging
- Ferroptosis detection assays
- Drug screening using reporter cell lines
- Writing and publishing scientific articles
- Presenting data in meetings
- Excellent communication skills
Molecular Biology:
Cell Culture:
Immunology:
Tumor Models:
Other Skills:
Accomplishments
Publications
Shuyin Li , Jason W. Shapiro, Hardik Shah, Emily F. Higgs, Lishi Xie, Yaopeng Li, Yuanyuan Zha, Jonathan Trujillo, Alexandra Cabanov, Tyler A Jones, Blake Flood, Ken Hatogai, Ruxandra Tonea, Justin Kline, and Thomas F. Gajewski. Tumor cell-intrinsic Decr2 is necessary for immunotherapy efficacy. Cancer Immunology Research, Under Revision.
Jason B Williams, Shuyin Li , Emily F Higgs, Alexandra Cabanov, Xiaozhong Wang, Haochu Huang, Thomas F Gajewski. Tumor heterogeneity and clonal cooperation influence the immune selection of IFN-γ-signaling mutant cancer cells. Nature Communications, 2020 Jan ( The first two authors contributed equally)
Blake A. Flood, Emily F. Higgs, Shuyin Li , Jason J. Luke, Thomas F. Gajewski. STING pathway agonism as a cancer therapeutic. Immunological Reviews, 2019 Jul.
Shuyin Li , Jun Liu, Qing Min, Tomokatsu Ikawa, Shoya Yasuda, Yang Yang, Yan‑Qing Wang, Takeshi Tsubata, Yaofeng Zhao, and Ji‑Yang Wang. Kelch-like protein 14 promotes B-1a but suppresses B-1b cell development. Int Immunol, 2018 Jun
Jason Perera, Zhong Zheng, Shuyin Li , Herman Gudjonson, Olga Kalinina, Jennifer I.C. Benichou, Katharine E. Block, Yoram Louzoun, Dengping Yin, Anita S. Chong, Aaron R. Dinner, Martin Weigert, Haochu Huang. Self-Antigen-Driven Thymic B Cell Class Switching Promotes T Cell Central Tolerance. Cell Reports, 2016 Oct
Li, S. , Zhao, Y., and Wang, J.Y. Analysis of Ig gene hypermutation in Ung-/-Polh-/- mice suggests that UNG and A:T mutagenesis pathway target different U:G lesions. Molecular immunology, 2013 Mar.
Li, Y., Li, S. , Hoshino, M., Ishikawa, R., Kajiwara, C., Gao, X., Zhao, Y., Ishido, S., Udono, H., and Wang, J.Y. HSP90α deficiency does not affect immunoglobulin gene hypermutation and class switch but causes enhanced MHC class II antigen presentation. Int Immunol, 2012 Dec. ( The first two authors contributed equally )
Conference and Presentations
April. 2024 American Association for Cancer Research, Poster presentation
Nov. 2019 Society for Immunotherapy of Cancer Conference
Oral presentation
Nov. 2018 Society for Immunotherapy of Cancer Conference
Nov.2017 Society for Immunotherapy of Cancer Conference
Nov.2016 Autumn Immunology Conference
Dec. 2015 COI WIP, Presentation
Apr. 2015 Autumn Immunology Conference
Apr. 2015 COI WIP, Presentation
Dec. 2010 Japanese Society for Immunology, Oral Presentation
Aug. 2010 International Congress of Immunology, Oral Presentation
Honors and Awards
2019 Young Investigator Award, SITC 34th Annual meeting
2007 Outstanding Graduate Student, China Agricultural University
2007 Best Thesis, China Agricultural University
2006 Third-class Scholarship, China Agricultural University
2006 Third-class Scholarship, China Agricultural University
2005 Merit Student, China Agricultural University
2003 Second-class Scholarship, China Agricultural University
Languages
English
Full Professional
Affiliations
The university of Chicago
Department of pathology-Thomas Gajewski Laboratory
929 E57th street GCIS W423H
Chicago, IL, 60637
Timeline
Research Professional
University of Chicago
08.2019 - Current
Postdoctoral Researcher
University of Chicago
08.2016 - 07.2019
Postdoctoral Researcher
University of Chicago
08.2014 - 07.2016
Intern
Fudan University
12.2013 - 04.2014
Ph.D. - Biology
China Agriculture University
Ph.D. - Immunology
RIKEN
Bachelor of Science - Biology
China Agriculture University
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