Tapas Bhattacharyya

• Highly experienced , self motivated researcher with demonstrated ability in the area of cell & molecular biology, microbiology, drug discovery, protein crystallography , genomics and molecular imaging.
• Highly skilled in genome editing (CRISPR-Cas), high-throughput screening of drug molecule & Protein purification.
• Capable of designing, optimization & implementation of research project & training
• Motivated towards developing new strategies, tools or techniques to solve a biological problem
• Interested in Molecular Biology application for Drug discovery, molecular diagnosis, synthetic biology application, protein engineering and creating stable cell line.

• Archiving & screening of a small molecule library of 11000 molecules against bacterial pathogen to identify potential broad spectrum novel antibacterial molecule IITR06144.
• Discovery of an efflux pump inhibitor, a small molecule, IITR08027 which restore the activity of several antibiotics which no longer effective against multidrug resistance Acinetobacter baumannii.
• TEM-1 β-lactamase from E.coli was purified and crystallized. The native crystals of TEM-1 β-lactamase was soaked into potential inhibitor and soaked crystal was diffracted in X ray to a resolution of 2.0
• Established stable CRISPR knock-in lines where 8kb of external DNA was introduced in rosa-26 locus of mouse genome.
• Established stable CRISPR deletion lines where 1kb of mouse genomic DNA from a specific location was deleted.
• High-throughput PCR based screening of of CRISPR edited clonal lines to identify mono-allelic of bi-allelic insertion or deletion.

https://scholar.google.co.in/citations?user=RBgim4oAAAAJ&hl=en

H1B, Sponsored by Michigan State University from June-2023