Summary
Overview
Work History
Education
Skills
Awards and Honors
Publications
Timeline
Generic

Adeline Matschulat

Boston,MA

Summary

Research Scientist with over 13 years of experience in clinical and academic research, excelling in project management and data analysis. Demonstrates a strong track record in securing competitive funding, including NIH grants, and contributing to impactful publications in iPSC therapy, oncology, and infectious diseases. Dedicated to fostering collaboration, innovation, and efficiency, I am eager to leverage my scientific research and writing expertise to advance biomedical science and improve treatment strategies for human disease.

Overview

13
13
years of professional experience

Work History

Graduate Student

Boston University School of Medicine
Boston, MA
08.2017 - 11.2024
  • Secured NIH F31 and pulmonary T32 grants supporting four years of graduate research.
  • Authored annual NIH RPPRs detailing research progress, challenges, and evolving goals.
  • Received multiple travel awards for research excellence and science communication.
  • Co-authored six peer-reviewed publications in iPSC therapy, oncology, and infectious disease; coordinated manuscript revisions with collaborators and journal editors.
  • Led lung stem cell projects as a subject matter expert in lung disease therapeutics.
  • Developed protocols for 3D organoid processing, immunohistochemistry, and CellProfiler analysis of organoid and ALI cultures.
  • Performed single-cell RNA-seq analysis using R and created custom R and CellProfiler pipelines to enhance workflow and data interpretation.
  • Presented findings at national conferences, seminars, and collaborative meetings.
  • Trained undergraduate and graduate students in lab techniques from basic prep to advanced tissue processing and cell culture; wrote recommendation letters for student applications.
  • Maintained detailed lab notebooks to ensure data transparency and reproducibility.

Professional Research Assistant

University of Colorado Anschutz Medical Campus
Aurora, CO
05.2014 - 08.2017
  • Helped develop a novel in vivo IgG-driven model of Multiple Sclerosis (MS).
  • Conducted and interpreted data from diverse assays to ensure alignment with protocols.
  • Co-authored 3 publications, including the identification of a putative MS biomarker, proteolipid protein 1.
  • Communicated expectations, deliverables, and timelines across team members and collaborators.
  • Performed assays on recombinant antibodies derived from MS patient CSF, advancing diagnostics and translational applications.
  • Administered precise intracranial injections in mice to study MS-related humoral mechanisms.
  • Maintained an antibody efficacy log, summarizing histological outcomes for antibody testing.
  • Oversaw lab operations and optimized procurement to support research efficiency.
  • Processed and biobanked CSF samples from MS patients and healthy donors for clinical research at the Rocky Mountain MS Center.
  • Maintained a detailed, widely referenced lab notebook to support data reproducibility.
  • Regularly shared research progress with the PI and lab team.
  • Presented posters at the University of Colorado Anschutz Neurology Retreat and the American Society for Neurochemistry Annual Meeting, honing presentation skills and building scientific networks.

Lab Technician II

National Jewish Health
Denver, CO
08.2013 - 04.2014
  • Managed transgenic mice colonies, ensuring desired genotypes would be produced.
  • Performed DNA extraction and genotyping via gel electrophoresis, ensuring that only mice with the desired genotype were selected for downstream experiments.
  • Kept detailed logs of mouse records including genotype, age, weight, and sex.
  • Maintained a detailed lab notebook, serving as a weekly reference and guide for upcoming experiments and tasks.
  • Prepared lung tissue for histological analysis, supporting critical research projects.
  • Conducted lab maintenance and procurement, optimizing operational efficiency.

Lab Technician I

National Jewish Health
Denver, CO
09.2012 - 06.2013
  • Assisted in recovering primary cells from patient lungs, requiring meticulous attention to detail, swift execution, and strong troubleshooting skills in real-time.
  • Isolated human lung macrophages and epithelial cells, essential for downstream analysis of the effect of Influenza A on cell viability and immune response.
  • Conducted plaque assays to precisely determine viral titers for use in downstream experiments involving primary lung macrophages and epithelial cells.
  • Managed lab maintenance and purchasing, optimizing resources, and reducing downtime.
  • Maintained detailed and organized lab notebooks, essential for data accuracy and experimental reproducibility.

Undergraduate Research Assistant

Barbara Davis Center for Diabetes – University of Colorado Anschutz Medical Campus
Aurora, CO
09.2011 - 08.2012
  • Conducted research for undergraduate thesis: HLA Genotypes in Type 1 Diabetes (T1D): Frequency Distribution of High-Risk Haplotypes in New Onset Patients.
  • Extracted and purified DNA from patient blood samples for high-quality genetic analysis.
  • Genotyped HLA alleles using PCR-based sequence-specific oligonucleotide probes, contributing to a patient database of T1D-associated high-risk haplotypes.
  • Analyzed high-risk alleles to inform early intervention strategies for at-risk individuals, particularly youth.
  • Trained undergraduates and new lab members in essential techniques, fostering a collaborative learning environment.
  • Maintained detailed lab notebooks, protocols, and secure patient databases to ensure data accuracy and confidentiality.
  • Participated in weekly lab meetings to promote transparency and collaborative problem-solving.

Education

PhD - Biochemistry and Cell Biology

Boston University School of Medicine
Boston, MA
11-2024

B.S. - Molecular Biology, Chemistry, Psychology

University of Denver
Denver, CO
05-2012

Skills

Wet Lab Techniques:Western blotting, multicolor flow cytometry/FACS, ELISA, gel electrophoresis, qPCR, DNA/RNA extraction, bacterial culture and plasmid prep, primary and immortalized cell culture, ALI culturing (human/mouse bronchial epithelial cells), iPSC culture, cell transduction/transfection, tracheal and lung organoid development, exosome and antibody purification, tissue prep, IHC, IF, RNA-FISH, confocal/fluorescence microscopy, buffer preparation

Animal Research: Mouse handling, breeding, weaning, genotyping, euthanasia

In Vivo Techniques: IP, SC, IC, IV, and retro-orbital injections; oral gavage; drug/tamoxifen dosing; tissue dissection for histology, biochemistry, and sequencing

Programming & Software: R, LoupeR, BioTuring, CellProfiler, FlowJo, Microsoft Office, Adobe (Acrobat, Illustrator, Photoshop), EndNote, Zotero

Scientific Expertise:Biomedical science, cell biology, lung biology, immunology, and biochemistry

Awards and Honors

  • Invited speaker for Keystone Symposia Lung Development, Infection, Repair and Aging (2023)
  • Henry I Russek Student Achievement Day Award Biochemistry, First (2023) and Second Prize (2022)
  • BU Genome Science Institute Symposium Award (2021)
  • Franzblau Travel Award (2019-2023)

Publications

Manuscript in preparation:

Matschulat, A.M., Cheng, N., Etesami, N., Yu, L., Shenoy, A., Ning, B., Lenburg, M., Mizgerd, J.P., Beane, J., Varelas, X. LATS1/2 Inactivation in the airway secretory epithelium drives AT1-like plasticity that is coupled to progressive inflammation and fibrosis.

Blauth, K., Soltys, J., Matschulat, A., Reiter, C. R., Ritchie, A., Baird, N. L., Bennett, J. L., & Owens, G. P. (2015). Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid cause demyelination of spinal cord explants. Acta Neuropathologica, 130(6), 765–781. https://doi.org/10.1007/s00401-015-1500-6

Burgess, C. L., Huang, J., Bawa, P. S., Alysandratos, K.-D., Minakin, K., Ayers, L. J., Morley, M. P., Babu, A., Villacorta-Martin, C., Yampolskaya, M., Hinds, A., Thapa, B. R., Wang, F., Matschulat, A., Mehta, P., Morrisey, E. E., Varelas, X., & Kotton, D. N. (2024). Generation of human alveolar epithelial type I cells from pluripotent stem cells. Cell Stem Cell, 31(5), 657-675.e8. https://doi.org/10.1016/j.stem.2024.03.017

Etesami, N. S., Barker, K. A., Shenoy, A. T., De Ana, C. L., Arafa, E. I., Grifno, G. N., Matschulat, A. M., Vannini, M. E., Pihl, R. M. F., Breen, M. P., Soucy, A. M., Goltry, W. N., Ha, C. T., Betsuyaku, H., Browning, J. L., Varelas, X., Traber, K. E., Jones, M. R., Quinton, L. J., … Mizgerd, J. P. (2024). B cells in the pneumococcus-infected lung are heterogeneous and require CD4+ T cell help including CD40L to become resident memory B cells. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1382638

Hicks-Berthet, J., Ning, B., Federico, A., Tilston-Lunel, A., Matschulat, A., Ai, X., Lenburg, M. E., Beane, J., Monti, S., & Varelas, X. (2021). Yap/Taz inhibit goblet cell fate to maintain lung epithelial homeostasis. Cell Reports, 36(2), 109347. https://doi.org/10.1016/j.celrep.2021.109347

Liu, Y., Given, K. S., Harlow, D. E., Matschulat, A. M., Macklin, W. B., Bennett, J. L., & Owens, G. P. (2017). Myelin-specific multiple sclerosis antibodies cause complement-dependent oligodendrocyte loss and demyelination. Acta Neuropathologica Communications, 5(1). https://doi.org/10.1186/s40478-017-0428-6

Mason-Osann, E., Dai, A., Floro, J., Lock, Y. J., Reiss, M., Gali, H., Matschulat, A., Labadorf, A., & Flynn, R. L. (2018). Identification of a novel gene fusion in ALT positive osteosarcoma. Oncotarget, 9(67), 32868–32880. https://doi.org/10.18632/oncotarget.26029

Na, E., Allen, E., Baird, L. A., Odom, C. V., Korkmaz, F. T., Shenoy, A. T., Matschulat, A. M., Jones, M. R., Kotton, D. N., Mizgerd, J. P., Varelas, X., Traber, K. E., & Quinton, L. J. (2022). Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia. American Journal of Physiology-Lung Cellular and Molecular Physiology, 322(4), L550–L563. https://doi.org/10.1152/ajplung.00325.2021

Ning, B., Tilston-Lunel, A. M., Simonetti, J., Hicks-Berthet, J., Matschulat, A., Pfefferkorn, R., Spira, A., Edwards, M., Mazzilli, S., Lenburg, M. E., Beane, J. E., & Varelas, X. (2023). Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression. Journal of Experimental & Clinical Cancer Research, 42(1). https://doi.org/10.1186/s13046-023-02674-5

Owens, G. P., Fellin, T. J., Matschulat, A., Salas, V., Schaller, K. L., Given, K. S., Ritchie, A. M., Navarro, A., Blauth, K., Hughes, E. G., Macklin, W. B., & Bennett, J. L. (2023). Pathogenic myelin-specific antibodies in multiple sclerosis target conformational proteolipid protein 1–anchored membrane domains. Journal of Clinical Investigation, 133(19). https://doi.org/10.1172/jci162731

Timeline

Graduate Student

Boston University School of Medicine
08.2017 - 11.2024

Professional Research Assistant

University of Colorado Anschutz Medical Campus
05.2014 - 08.2017

Lab Technician II

National Jewish Health
08.2013 - 04.2014

Lab Technician I

National Jewish Health
09.2012 - 06.2013

Undergraduate Research Assistant

Barbara Davis Center for Diabetes – University of Colorado Anschutz Medical Campus
09.2011 - 08.2012

PhD - Biochemistry and Cell Biology

Boston University School of Medicine

B.S. - Molecular Biology, Chemistry, Psychology

University of Denver

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