Adeline Matschulat
Boston,MA
Summary
Scientist with over 13 years of experience in clinical and academic research, excelling in project management and data analysis. Demonstrates a strong track record in securing competitive funding, including NIH grants, and contributing to impactful publications on iPSC therapy, oncology, and infectious diseases. Dedicated to fostering collaboration, innovation, and efficiency and I am eager to leverage my scientific research and writing expertise to advance biomedical science and improve treatment strategies for human disease.
Overview
13
13
years of professional experience
Work History
Graduate Student
Boston University School of Medicine
Boston, USA
08.2017 - 11.2024
- Secured NIH F31 and pulmonary T32 grants supporting five years of graduate research.
- Authored annual NIH RPPRs detailing research progress, challenges, and evolving goals.
- Received multiple travel awards for research excellence and science communication.
- Co-authored six peer-reviewed publications in the fields of iPSC therapy, oncology, and infectious disease; coordinated manuscript revisions with collaborators and journal editors.
- Led lung stem cell projects as a subject matter expert in lung disease therapeutics.
- Developed protocols for 3D organoid processing, immunohistochemistry, and CellProfiler analysis of organoid and ALI cultures.
- Conducted iPSC directed differentiation into lung epithelial cells.
- Performed single-cell RNA-seq experiments and subsequent analysis using R and created custom R and CellProfiler pipelines to enhance workflow and data interpretation.
- Presented findings at national conferences, seminars, and collaborative meetings.
- Trained undergraduate and graduate students in lab techniques from basic prep to advanced tissue processing and cell culture; wrote recommendation letters for student applications.
- Maintained detailed lab notebooks to ensure data transparency and reproducibility.
- Initiated collaboration with in house and external research teams.
Professional Research Assistant
University of Colorado Anschutz Medical Campus
Aurora, USA
05.2014 - 08.2017
- Helped to develop a novel in vivo IgG-driven model of Multiple Sclerosis (MS).
- Conducted and interpreted data from diverse assays to ensure alignment with protocols.
- Co-authored 3 publications, including the identification of a putative MS biomarker, proteolipid protein 1.
- Communicated expectations, deliverables, and timelines across team members and collaborators.
- Performed assays on recombinant antibodies derived from MS patient CSF, advancing diagnostics and translational applications.
- Administered precise intracranial injections in mice to study MS-related humoral mechanisms.
- Maintained an antibody efficacy log, summarizing histological outcomes for antibody testing.
- Oversaw lab operations and optimized procurement to support research efficiency.
- Processed and biobanked CSF samples from MS patients and healthy donors for clinical research at the Rocky Mountain MS Center.
- Maintained a detailed, widely referenced lab notebook to support data reproducibility.
- Regularly shared research progress with the PI and lab team.
- Presented posters at the University of Colorado Anschutz Neurology Retreat and the American Society for Neurochemistry Annual Meeting, honing presentation skills and building scientific networks.
Lab Technician II
National Jewish Health
Denver, USA
08.2013 - 04.2014
- Managed transgenic mice colonies, ensuring desired genotypes would be produced.
- Performed DNA extraction and genotyping via gel electrophoresis, ensuring that only mice with the desired genotype were selected for downstream experiments.
- Kept detailed logs of mouse records including genotype, age, weight, and sex.
- Maintained a detailed lab notebook, serving as a weekly reference and guide for upcoming experiments and tasks.
- Prepared lung tissue for histological analysis, supporting critical research projects.
- Conducted lab maintenance and procurement, optimizing operational efficiency.
Lab Technician I
National Jewish Health
Denver, USA
09.2012 - 06.2013
- Assisted in recovering primary cells from patient lungs, requiring meticulous attention to detail, swift execution, and strong troubleshooting skills in real-time.
- Isolated human lung macrophages and epithelial cells, essential for downstream analysis of the effect of Influenza A on cell viability and immune response.
- Conducted plaque assays to precisely determine viral titers for use in downstream experiments involving primary lung macrophages and epithelial cells.
- Managed lab maintenance and purchasing, optimizing resources, and reducing downtime.
- Maintained detailed and organized lab notebooks, essential for data accuracy and experimental reproducibility.
Undergraduate Research Assistant
Barbara Davis Center for Diabetes
Aurora, USA
09.2011 - 08.2012
- Conducted research for undergraduate thesis: HLA Genotypes in Type 1 Diabetes (T1D): Frequency Distribution of High-Risk Haplotypes in New Onset Patients.
- Extracted and purified DNA from patient blood samples for genetic analysis.
- Helped design and outline patient consent forms.
- Participated in matching patients with on-going clinical trials.
- Genotyped HLA alleles using PCR-based sequence-specific oligonucleotide probes, contributing to a patient database of T1D-associated high-risk haplotypes.
- Analyzed high-risk alleles to inform early intervention strategies for at-risk individuals, particularly youth.
- Trained undergraduates and new lab members in essential techniques, fostering a collaborative learning environment.
- Maintained detailed lab notebooks, protocols, and secure patient databases to ensure data accuracy and confidentiality.
- Participated in weekly lab meetings to promote transparency and collaboration.
Education
PhD - Biochemistry and Cell Biology
Boston University School of Medicine
Boston, MA11-2024
B.S. - Molecular Biology, Chemistry, Psychology
University of Denver
Denver, CO05-2012
Publications (Orchid ID)
https://orcid.org/0000-0001-5288-1434
Timeline
Graduate Student
Boston University School of Medicine
08.2017 - 11.2024
Professional Research Assistant
University of Colorado Anschutz Medical Campus
05.2014 - 08.2017
Lab Technician II
National Jewish Health
08.2013 - 04.2014
Lab Technician I
National Jewish Health
09.2012 - 06.2013
Undergraduate Research Assistant
Barbara Davis Center for Diabetes
09.2011 - 08.2012
PhD - Biochemistry and Cell Biology
Boston University School of Medicine
B.S. - Molecular Biology, Chemistry, Psychology
University of Denver
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