Adele Mossa

• Submitted, as the first author, the revised manuscript “Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X” to Nature Communications on November 2024. This project has been funded by the Doft Family/Friedman Brain Institute Postdoctoral Innovator Award and the Brain and Behavior Research Foundation Young Investigator Grant.
• Co-author of the review "DEAD/DEAH-box RNA helicases shaping risk for neurodevelopmental disorders" submitted to Trends in Genetics on October 2024.

• Led the project aimed to investigate the role of the cerebellar development and its connectivity to the cortex in DDX3X syndrome. This work has been supported by the Beatrice & Samuel A. Seaver Foundation Fellowship and the Uplifting Athletes Young Investigator Grant.
• Characterized the motor phenotypes of the first knock-in mouse model of EXOSC3 pontocerebellar hypoplasia type 1B, as collaborator of the Marazzi lab.
• Published, as the first author, the review "Molecular causes of sex-specific deficits in rodent models of neurodevelopmental disorders" (Mossa A. et al., J Neurosci Res, 2021).
• Published, as the first author, the Ph.D. project that pinpointed the AKT signaling as a potential therapeutic target to rescue deficits in a mouse model related to Phelan-McDermid syndrome. (Mossa A. et al., Mol Psychiatry, 2021)

• Contributed, as the co-first author, to identify, by integrating molecular, behavioral and pharmacological approaches, the cAMP signaling as a sex-specific therapeutic target in a mouse model with mutations in Cc2d1a, which cause a rare form of intellectual disability (Zamarbide M, Mossa A, et al., Biol Psychiatry, 2019).
• Published, as the first author, the review "SHANK genes in autism: Defining therapeutic targets" (Mossa A, et al., Prog Neuropsychopharmacol Biol Psychiatry, 2018).

Contributed to identify the eukaryotic elongation factor 2 kinase (eEF2K) as a potential novel target to ameliorate epileptic seizures in a mouse model of human epilepsy (Heise C. et al., Cereb Cortex; 2017).